Endocrine Abstracts

Primary lymphomas of the thyroid are uncommon tumours, constituting fewer than 2% of all thyroid malignancies. For this reason their clinical features are not very well known. It seems that most of them arise in patients who have chronic autoimmune thyroiditis.From our patients with primary thyroid cancer since 1995, we selected those with pathological diagnosis of thyroid lymphoma. Epidemiological data, clinical features and response to treatment were a...

Introduction: Hyponatremia is the most frequent electrolyte disorder in hospitalised patients. Our aim was to determine the incidence, mean hospital stay, readmission rate and mortality rate among patients with acute heart failure (HF) and hyponatremia.Methods: Retrospective analysis of data collected from the minimum data set (MDS) of Spanish National health System during 2005–2012 from discharged patients of Internal Medicine with HF and hyponatre...

Introduction: The prevalence of hyperthyroidism in patients admitted in Internal Medicine at Spanish hospitals is 0.8%. Proper diagnosis and management of HTD in these patients is still a challenge and therefore, the analyses of the factors involved in the prognosis and survival is of interest.Methods: Data from the minimum-data-set (MDS) of Spanish National health System were collected during 2005–2012 from discharged patients of Internal Medicine ...

Introduction: Hereditary phaeochromocytoma (PCC) and paraganglioma (PGL) account for 30–35% of cases and have some clinically relevant peculiarities.Material and methods: Retrospective, unicentric cohort study that included all genotyped patients (n=36, 27 with PCC and 9 with PGL) diagnosed at Hospital Clínico San Carlos (Madrid) between 1984 and 2013; 33% were germline mutation carriers (25% pseudohypoxic [PH] phenotype, 75% MAP-kinas...

Introduction: Hereditary Medullary Thyroid Cancer (MTC) accounts for 20–30% of cases and has some clinically relevant peculiarities.Material and methods: Retrospective, unicentric cohort study that included all genotyped patients with MTC (n=48) diagnosed at Hospital Clínico San Carlos (Madrid) between 1984–2013; 42% were germline mutation carriers (45% moderate risk (category MOD), 45% high risk (category H), 10% highest risk (ca...

Introduction: Hypothyroidism (hT) is a very common disease that can affect inpatients prognosis. We analysed the clinical profile of patients with hT admitted to Internal Medicine using a large clinical-administrative database.Methods: A descriptive analysis based on the minimum-data-set database of the Spanish National health System of patients who were discharged from the services of Internal Medicine with the diagnoses of hT during 2005–2012 was ...

Introduction: HypoPTH is an uncommon disorder, mostly due to anterior neck surgery. The prevalence of HypoPTH has been studied in surgical series and registries, (USA, Denmark and Hungary) where only a minority of patients has HypoPTH due to non-surgical causes. In Spain data on PO HypoPTH in endocrinologist clinical practice has been published recently. The aim of this study was to establish the prevalence of chronic PO HypoPTH in Bilbao area, with a population 2019: 346,843....

Introduction: Hyperaldosteronism can induce elevated parathyroid hormone (PTH) levels, presumably by increasing calciuria. Furthermore, PTH stimulates aldosterone secretion in vitro, and increases angiotensin–II-stimulated aldosterone release. In a patient with hyperaldosteronism and hyperparathyroidism, PTH receptors were detected in aldosteronoma tissue. We present three patients sent to an endocrinologist for treatment/follow-up of primary hyperparathyroidism,...

Introduction: In a majority of Spanish hospitals, serum sodium levels (SNa) are determined by indirect electrode methodology (sodium in the liquid fraction of serum) divided by the total serum volume (mmol/l). To avoid over/underestimating SNa, a formula can be applied: SNa corrected for total proteins (TP)=SNa×93 divided by (99.1−(0.7×TP)). Hypoproteinaemia is frequent in patients receiving parenteral nutrition (PN), and is probably related to surgery, acute d...

Context: Primary hyperparathyroidism (PHPT) is a common endocrine disease, characterized by the chronic elevation of serum calcium (Ca) levels induced by a long-standing increase of PTH concentrations. PHPT includes mild-asymptomatic and symptomatic forms. Cinacalcet is effective in lowering serum Ca levels in PHPT, but is indicated solely in mild-asymptomatic PHPT meeting surgery criteria. Management of non-surgical mild-asymptomatic PHPT is still a debated issue.<p class...